2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Thyroid Hormone Receptor

Thyroid Hormone Receptor

THR

Thyroid Hormone Receptor

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Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.

Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-19154
    Montirelin
    Montirelin (NS 3) is an analog of thyrotropin-releasing hormone (TRH), and exhibits high affinity to TRH receptors. Montirelin exhibits potent effects to central nervous system (CNS).
    Montirelin
  • HY-P4857
    pTH-Related Protein (7-34) amide (human, mouse, rat)
    pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent antagonist of parathyroid hormone (PTH).
    pTH-Related Protein (7-34) amide (human, mouse, rat)
  • HY-111983
    Etiroxate
    		Agonist
    Etiroxate (CG-635) is a lipid lowing compound which can be used for hyperlipoproteinemia research.
    Etiroxate
  • HY-143613A
    THR-β agonist 2 diacetate
    		Agonist
    THR-β agonist 2 diacetate (Compound 3) is a potent agonist of THR-β. THR-β agonist 2 diacetate has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases.
    THR-β agonist 2 diacetate
  • HY-147500
    TRβ agonist 2
    		Agonist
    TRβ agonist 2 (Compound 1) is a potent agonist of TRβ. TRβ agonist 2 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 2 is a new potential TRβ-selective thyromimetics.
    TRβ agonist 2
  • HY-18341BR
    L-Thyroxine sodium (Standard)
    L-Thyroxine (sodium) (Standard) is the analytical standard of L-Thyroxine (sodium). This product is intended for research and analytical applications. L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
    L-Thyroxine sodium (Standard)
  • HY-P4700
    pTH (53-84) (human)
    pTH (53-84) (human) is apTH ((Human parathyroid hormone) fragment.
    pTH (53-84) (human)
  • HY-153535
    THRβ receptor agonist-1
    		Agonist
    THRβ receptor agonist-1 is a THRβ receptor agonist.
    THRβ receptor agonist-1
  • HY-125787
    MLS000389544
    		Antagonist
    MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2).
    MLS000389544
  • HY-W010696AS
    Reverse T3-13C6 hydrochloride
    Reverse T3-13C6 (hydrochloride) is the 13C labeled Reverse T3.
    Reverse T3-<sup>13</sup>C<sub>6</sub> hydrochloride
  • HY-153637
    THR-β modulator-1
    		Modulator
    THR-β modulator-1 (compound 1a) is a potent thyroid hormone receptor β modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders.
    THR-β modulator-1
  • HY-P4696
    pTH (3-34) (bovine)
    pTH (3-34) (bovine) is apTH ((Human parathyroid hormone) fragment.
    pTH (3-34) (bovine)
  • HY-18341S4
    L-Thyroxine-13C6-1
    L-Thyroxine-13C6-1 (Levothyroxine-13C6-1; T4-13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
    L-Thyroxine-<sup>13</sup>C<sub>6</sub>-1
  • HY-B0596S
    Taltirelin-13C,d3
    		Agonist
    Taltirelin-13C,d3 (TA-0910-13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
    Taltirelin-<sup>13</sup>C,d<sub>3</sub>
  • HY-116325
    3,5,3'-Triiodo-D-thyronine
    		Activator
    3,5,3'-Triiodo-D-thyronine, a thyroid hormone, is less effective than 3,5,3'-Triiodo-T-thyronine in normalizing the increased plasma creatine phosphokinase (CPK) activity.
    3,5,3'-Triiodo-D-thyronine
  • HY-133846
    Iodothiouracil
    Iodothiouracil exhibits high selectivity for melanoma, remains stable in the melanin in melanoma cells, and localizes remote secondary metastases of melanoma. Iodothiouracil can be used for melanoma imaging when labeled with iodine-123, and can be used for radiation therapy when labeled with iodine-131.
    Iodothiouracil
  • HY-P4817
    Human PTH-(1-31)
    Human PTH-(1-31) is the 1-31 fragment of human PTH. Human PTH-(1-31) stimulates the release of cAMP and also is a weaker stimulator of the 25-hydroxyvitamin D-1α-hydroxylase. Human PTH-(1-31) induces bone formation without inducing bone resorption. Human PTH-(1-31) has the potential for the research of osteoporosis.
    Human PTH-(1-31)
  • HY-W713284
    2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate
    2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate is the deuterium labeled Octinoxate (HY-B1234). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.
    2-Ethylhexyl (E)-3-(4-(methoxy-d<sub>3</sub>)phenyl)acrylate
  • HY-12753AR
    Debutyldronedarone hydrochloride (Standard)
    		Inhibitor
    Debutyldronedarone (hydrochloride) (Standard) is the analytical standard of Debutyldronedarone (hydrochloride). This product is intended for research and analytical applications. Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic.
    Debutyldronedarone hydrochloride (Standard)
  • HY-120358
    L-6424
    		Inhibitor
    L-6424 inhibits T3 binding to α1-T3R and β1-T3R.
    L-6424
Cat. No. Product Name / Synonyms Application Reactivity